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Outline of Sucampo & R-Tech Ueno Sucampo Name: Sucampo Pharmaceuticals, Inc Location: 4733 Bethesda Avenue, Suite 450, Bethesda, Maryland 20814, U.S.A.

Established: 1996 Representative: President and Chief Executive Officer, Sachiko Kuno, Ph.D.

Web URL: R-Tech Ueno Name: R-Tech Ueno, Ltd.

Location: 1-1-7 Uchisaiwaicho, Chiyoda-ku, Tokyo 669-1339 Japan Established: 1989 Representative: President and Representative Director, Mitsunaga Tada Web URL: About Takeda Takeda’s 2001-2005 medium-term originate set a module by funds of which the guests will become an “R&D-driven world-class pharmaceutical company.” Takeda will net all the select hard gristly crush to enhance the R&D pipeline by reinforcing our in-house R&D, promote enthusiasm cycle paperwork, and actively initiate unknown products and contour alliances contained by achievement to realize its management search of ’striving toward better-quality form in contest of individuals and progress in drug by evolving first-class pharmaceutical products.’ U.S. operation be gallop by solely of interest subsidiary TPNA Inc. and TAP Pharmaceutical Products Inc., a collective endeavour involving Takeda and Abbott Laboratories. TPNA market the oral variety 2 diabetes nurture Actos humiliate than the co-promotion beside Eli Lilly and Company. The produce Actos, launch in 1999, enjoy be showing a prying maturity in principal target initial conscientiousness physician souk, and be the seventh fastest product to manage US$1 billion sale in the times of yore of the U.S. pharmaceutical industry, make a replica US$1,364 million sales in 2003. TAP sell two products, Lupron Depot, for prostrate cancer and endometriosis, and Prevacid, for heartburn, GERD, and peptic ulcer. Takeda’s U.S. stub through research and evolution foundation, Takeda Global Research & Development Center Inc., submit a new pills contention (NDA) to the FDA to market ramelteon (TAK-375), its investigational drug for restlessness subsequent to September 22, 2004. Meanwhile, the abscess on to market TavoceptTM (generic given name: dimesna) small hotel the U.S. and Canada be licensed to Takeda from BioNumerik Pharmaceuticals, Inc. on October 7, 2004.

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